Carpal tunnel syndrome is the most common peripheral compression syndrome, and may be present unilaterally or bilaterally. It is common in people who perform repetitive or forceful movements during work or play, and is also associated with medical conditions such as pregnancy, diabetes, and hypertension. Classic symptoms of CTS include intermittent pain or tingling along the median nerve distribution of the wrist, hand, thumb, and fingers. Physical and occupational therapy can help CTS patients manage painful symptoms and regain function in the hand. This course describes lifestyle changes that may benefit the patient with CTS and defines the role of the rehabilitation professional and goals of the rehabilitation program.